CeeTox’s robust, systems-biology approach has developed in vitro models with real predictive power.
We help you identify new drug candidates, chemicals, cosmetics, and consumer products that have the lowest risk for toxicity and the highest probability of success. CeeTox helps you bring safer products to market.
Acute Toxicity - LD50 Assay
The Acute Toxicity - LD50 Assay provides detailed information on the cytotoxicity of test articles using a multi-parameter, cell-based in vitro model. We use the data to rank-order compounds for cytotoxicity, identify potential subcellular targets and mechanisms of toxicity, and to provide an estimate of acute oral toxicity (the CTox LD50 value) based on the OECD system for categorizing chemicals (Very Toxic – Toxic – Harmful – Unclassified). In a study with 76 public domain compounds the assay showed:
Sensitivity - 88%
Specificity - 100%
The Acute Toxicity - LD50 Assay assesses in vitro results to predict the single dose LD50 value and category of toxicity with a high degree of concordance to known in vivo values.
SenCeeTox®, Skin Sensitization Assay
The in vitro alternative to predicting the human skin sensitization potency classification of chemicals, cosmetics and ingredients.
SenCeeTox® combines markers for cell viability, Nrf2 / ARE gene expression, and direct reactivity over concentration and time and is based on known steps in the sensitization process.
The assay is highly predictive of human sensitization. In a blinded study of 67 chemicals, the assay predicted the correct in vivo sensitization category with a sensitivity and specificity of:
Sensitivity - 81%
Specificity - 92%
Cosmetic Science Symposium and Expo 2013
October 23-24, 2013
American College of Toxicology
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